ANTIBACTERIAL ACTIVITY OF SOME NEWLY SYNTHESIZED PYRAZOLINE DERIVATIVES

Abstracts

 Pharmaceuticals and medical researchers keep investigating and working to find ‎and synthesize new drugs to treat various types of pathological conditions, and also ‎to overcome bacterial resistance to known antibiotics‎. Thirteen compounds were prepared referred as (C1-C13) from Parra aminoacetophenone after treated with sodium nitrite‎ in the presence of hydrochloric acid to get diazonium salt. (C1). Then compound (C1) was retreated with different aromatic aldehydes ‎‎(o- hydroxyl benzaldehyde, p- N, N-Di methyl benzaldehyde, - o ‎chlorobenzaldehyde; o-nitro benzaldehyde), to get (C2- C5). Then these ‎compound (C2- C5) ‎were treated with furfural to get Compound (C6-C9). Compounds (C6- C9). And the later compounds were re treated again with hydrazine hydrate to get compounds (C10- C13). The chemical structures of the synthesized products were structurally confirmed on ‎the basis of IR, characterized by (FT-IR) and (H-NMR) (10, 11) and melting points. The prepared compounds showed antibacterial activity against Staphylococcus aureus, E. coIi, KIebseilIa pneumonia,‎ and Pseudomonas aeruginosa. The results of this work ‎indicated a promises future for new antibacterial drugs.

Keywords : New pyrazoline derivatives; antibacterial chemicals; Parra aminoacetophenone. ‎

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Posted July 19, 2018 04:51